DISCOVER CUTTING EDGE IMMUNOLOGY RESEARCH AT QUEEN’S
Groundbreaking research is being undertaken at Queen’s, focusing on understanding the role of the immune system in health and disease, with a particular emphasis on the complex interaction between the immune system and infections.
This fundamental knowledge is essential to accelerating the discovery of vital and innovative approaches to combatting infectious diseases and immune diseases that affect large proportions of the population. Our virologists direct research on the most prevalent human respiratory viruses, including now SARS-CoV-2, applying a multidisciplinary approach to dissect virus-host interaction to develop new treatments and vaccines.
Our immunologists have a strong research focus on innate and adaptive inflammatory responses associated with diseases such as allergy, infection, and autoimmunity. While understanding the mechanisms of inflammation is important, it is equally important to decrypt mechanisms that drive tissue repair and regeneration. A number of new initiatives within Queen’s immunology research groups aim to harness the power of the immune system to treat acute and chronic diseases.
IMMUNOLOGY AND THE TREATMENT OF INFLAMMATORY DISEASES
- MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
- A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
- Regulating metabolic inflammation by nutritional modulation
- Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals
- Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa
- NLRP3 inflammasome priming: a riddle wrapped in a mystery inside an enigma
- Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity
- T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells
- Histamine Produced by Gram-Negative Bacteria Impairs Neutrophil's Antimicrobial Response by Engaging the Histamine 2 Receptor
- Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1bin platelets
VIROLOGY AND TREATMENT OF RESPIRATORY INFECTIONS
- SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
- Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury
- Different endotypes and phenotypes drive the heterogeneity in severe asthma
- Lung function and microbiota diversity in cystic fibrosis
- Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis
IMMUNOLOGY AND MICROBES RESEARCHERS
Dr Adrien Kissenpfennig (Reader)
Dr Karim Dib (Senior Lecturer)
Dr Rebecca Ingram (Senior Lecturer)
Dr Selinda Orr (Senior Lecturer)
Dr Rebecca Coll (Lecturer)
Dr David Courtney (Lecturer)
Dr Yvonne Dombrowski (Lecturer)
Dr Effie Kostareli (Lecturer)
Dr Guillermo Lopez Campos (Lecturer)
Dr Aurelie Mousnier (Lecturer)
Dr Gunnar Schroeder (Lecturer)
Dr Tom Waterfield (Clinical Lecturer)
Dr David Cisneros (Lecturer)
Dr Dessi Malinova (Patrick G Johnston Fellow)