Skip to Content

Antibacterial activity and mode of action of phytochemicals against resistant bacteria of health and economic importance

School of Biological Sciences | PHD
Funding
Unfunded
Reference Number
SBIO-2020-1214
Application Deadline
None specified
Start Date
None specified

Overview

Antimicrobial resistance (AMR) has been declared by WHO as one of the top global public health threats facing humanity. Misuse and overuse of antimicrobials are the main drivers in the development of drug-resistant pathogens. This project aims to evaluate phytochemicals as safe, effective and sustainable antibiotic alternatives to combat AMR.

The widespread use and heavy reliance on antimicrobials across human and veterinary medicine as well as agricultural food production have inevitably resulted in the emergence of antimicrobial resistance (AMR) which is now one of the biggest threats to the One-Health system, i.e. human, animal, food security and environmental health. The pace at which bacteria develop their resistance has been alarming compared to the development of new antibiotics. This limits treatments of infections with fewer and less sensitive antibiotics. Reducing unnecessary use of antibiotics to preserve effectiveness of existing antimicrobials, and utilising antibiotic alternatives are among the current global actions to combat AMR. The urgent need for antibiotic alternatives sparks a revival of interest in exploiting the ancient knowledge of medicinal plants to tackle the modern challenge of AMR. The continual use of traditional medicines to date in many parts of the world supports the anecdotal effectiveness of phytochemicals against human and animal infections. This project seeks to provide scientific evidence of the efficacy of plant substances (phytochemicals) against resistant bacteria in humans and animals, and to elucidate their underlying antibacterial mechanisms using contemporary scientific tools and advanced technological platforms interlinking different disciplines of microbiology, biochemistry, molecular biology and biotechnology.

Project Summary
Supervisor

Dr Chen Situ

Research Profile


Mode of Study

Full-time: 3 Years


Apply now Register your interest