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Deciphering the role of the ocular glymphatic system in diabetic retinopathy

School of Medicine, Dentistry and Biomedical Sciences | PHD
Funding
Funded
Reference Number
SMED-2251-1024
Application Deadline
25 February 2025
Start Date
1 October 2025

Overview

There is an urgent need to identify novel treatments for Diabetic Retinopathy, a sight-threatening side effect of diabetes. This project will use state-of-the-art approaches to elucidate the role that glymphatic clearance plays in the development of Diabetic Retinopathy.

Diabetic retinopathy (DR) is a sight-threatening complication of diabetes. Current treatments for DR prevent further damage to retinal blood vessels but do not address the earlier stages of the disease, where the neurovascular unit (NVU) may become disrupted and damaged. People with Diabetes also have a two-fold increased risk of developing Alzheimer’s disease (AD) where there could be shared pathophysiological processes between brain and retina. During AD, accumulation of toxic amyloid beta occurs due to dysfunction of the brain’s waste clearance system (the glymphatic system).

Recent research suggests that the retina also possesses a glymphatic clearance system which is dependent on integrity of the NVU and especially on the homeostatic role of the Müller glia. All cells of the retinal NVU are known to become dysfunctional during DR although we have little knowledge about the role of the glymphatic system during diabetes. Understanding this system will provide an important therapeutic opportunity and also go some way to explaining the established linkage between visual and cognitive decline, especially in type 2 diabetes.

This project will investigate the retinal glymphatic system in the context of DR. Using a range of molecular biology techniques alongside in vivo measurements of glymphatic clearance, this research will further our understanding of the glymphatic system and its role in Diabetic Retinopathy. In this exciting project, the student will have the opportunity to develop a range of research skills including cell biology and molecular biology techniques (e.g. PCR, western blot, immunohistochemistry) as well as working with pre-clinical models of diabetes and AD.

Funding Information

Funded by the Department for the Economy (DfE). For eligible students the value of an award includes the cost of approved tuition fees and maintenance support. The 2025/26 rates are still to be confirmed (current rates for 2024/25 are Fees £4,786, Stipend £19,237).

For further information about eligibility criteria please refer to the DfE Postgraduate Studentship Terms and Conditions at https://www.economy-ni.gov.uk/publications/student-finance-postgraduate-studentships-terms-and-conditions

Project Summary
Supervisor

Dr Karis Little


Mode of Study

Full-time: 3 Years


Funding Body
DfE
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