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Exploration of the role of exosomes in RSV pathogenesis in airway epithelium. (International)

School of Medicine, Dentistry and Biomedical Sciences | PHD

Applications are now CLOSED
Funding
Funded
Reference Number
SMED-2231-1230
Application Deadline
None specified
Start Date
None specified

Overview

Exosomes are small extracellular vesicles released from cells that play important roles in cell-to-cell communications. Increasing evidence suggests they are also important in responses to virus infections. This project will determine their role in the pathogenesis of RSV, a major cause of severe lung disease in infants and the elderly

Respiratory syncytial virus (RS) is a major cause of severe lung disease in young infants and the elderly. However, the mechanisms by which is causes disease are poorly understood. The primary targets for RSV infection are the ciliated epithelial cells lining the airways. Our laboratory has expertise in culturing primary human airway epithelial cells so that they look and behave like they do in the nose and lungs. We have used them to establish models of RSV infection that reproduce many hallmarks of RSV disease. Increasing evidence indicates that RSV disease is caused primarily by an over-exuberant immune response to infection, with massive infiltration of immune cells to the lungs. Infected epithelial cells, therefore, are likely central to initiation of the disease process.
Exosomes are small extracellular vesicles released from cells that play important roles in intracellular communication. They are also important in responses to virus infections. Exosomes contain proteins, lipids, and non-coding (nc)RNAs. However, their role in the immunopathogenesis of RSV disease is unclear. This project will exploit our primary airway epithelial cell culture models of RSV infection to systematically study the role of exosomes released in response to RSV infection in virus cytopathogenesis.

Funding Information

Project Summary
Supervisor

Professor Ultan Power

Research Profile


Mode of Study

Full-time: 3 Years


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