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Improving nutrient utilisation, animal health, and food production efficiency via dietary directed modulation of the intestinal barrier

School of Biological Sciences | PHD
Funding
Unfunded
Reference Number
SBIO-2020-1212
Application Deadline
None specified
Start Date
None specified

Overview

New feed technologies are required to increase efficiency and reduce the environmental impact of primary food production, helping animal-based sectors meet the challenges of future policy changes.

The gastrointestinal tract is lined by a monolayer of epithelial cells that play a key role in immunological defence and nutrient absorption processes, with the epithelial layer connected by tight junctions that act as a physical barrier to passage from the intestinal lumen. As an important determinant of intestinal permeation, the bioavailability of nutrients is dependent on the quality of epithelial layer barrier functioning. Dietary components have been shown to impact the integrity of epithelial cells modulating protein expression profiles and secretion of inflammatory cytokines. This project will aim to develop new knowledge on the effects of key dietary components on the intestinal environment with the objectives of informing the design and development of new improved formulated feeds for commercial applications which will enhance production efficiency. In vitro intestinal model systems and assays will be developed which will help screen and study the impact of various parameters on nutrient availability and transport and assess dietary component effects on barrier integrity and permeability. Validation of observed in vitro alterations will be correlated through performance of in vivo feeding studies in relevant species where biological and production level performance parameters will be monitored as determinants of altered intestinal nutrient functioning and processing.

Project Summary
Supervisor

Professor Mark Mooney

Research Profile


Mode of Study

Full-time: 3 Years


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