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Vaccine-drying stabilisation strategies

School of Pharmacy | PHD
Funding
Unfunded
Reference Number
PMY/2251/VK2
Application Deadline
31 January 2025
Start Date
1 October 2025

Overview

Needle-free vaccines offer the possibility to develop new formats that improve both immune response and improve global access, by reducing cost to manufacture and improving stability at higher temperatures. In this project new formulation and drying strategies will be investigated, focussing on nasal and inhaled routes and including encapsulation into liposomal nanoparticles. Extensive training will be provided in all aspects of the fundamentals of nanoparticle manufacture, lyophilisation and spray-drying together with physicochemical methods required to optimise the drying methods for the specific requirements of the antigen, and to characterise vaccine products such as mucoadhesion for nasal delivery, thermal stability, release and powder properties. Successful applicants will demonstrate a keen interest in development of vaccines and a desire to make a significant contribution to the field. Candidates should be motivated team-players with the ability to learn quickly, work with ambition and integrity and proactively develop their research. Effective communication should be demonstrated by a strong application and CV specifically tailored to this studentship.

Vaccine formulation

Freeze-drying and spray-drying technology 
preparation and characterisation of liposomal nanoparticles 
in vitro drug release testing 
thermal analysis methods 
planning and organising skills: designing and planning of experiments 
numeracy and statistical skills 
teamwork skills

This project is aligned with ongoing research in the research group and is expected to contribute towards significant research publications demonstrating the potential to improve the accessibility to vaccines globally.