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​​A proliposomal strategy for enhancing solubility and absorption of drugs delivered from controlled release vaginal ring devices ​

School of Pharmacy | PHD
Funding
Unfunded
Reference Number
PMY/2251/KM8
Application Deadline
31 January 2025
Start Date
1 October 2025

Overview

Controlled release vaginal rings are used for long-term administration of drugs to the human vagina. Currently, eight ring devices have reached market, mostly focused on estrogen replacement therapy, hormonal contraception, and HIV prevention. The team at QUB are world-renowned for their knowledge and expertise in this area. Liposomes are nano-sized, spherical vesicles composed of one or more phospholipid bilayers surrounding an aqueous core. They are increasingly used in drug products due to their unique ability to encapsulate both hydrophilic (water-soluble) and hydrophobic (fat-soluble) substances. Most liposomes are formulated as colloidal aqueous suspensions, which may be freeze-dried to improve stability and then reconstituted later. There is also interest in proliposomal formulations, in which the component excipients that constitute liposomes are formulated as free-flowing powders that transform into liposomes when they come into contact with water or other biological fluids. In this this project, we will—for the first time—attempt to incorporate proliposomal formulations into silicone elastomer or thermoplastic vaginal rings, as part of efforts to overcome the solubility/absorption constraints of certain highly lipophilic drug actives.

The project will provide high-quality, industrially-relevant training and skills in the formulation development and testing of controlled release drug products, and drug-releasing vaginal rings in particular.

Device manufacture (by injection molding/hot melt extrusion)

Formulation

Drug product testing / analytical methods

This project will leverage the expertise of the Malcolm/Boyd and Tian research groups to develop new drug delivery devices suitable for addressing clinical indications relating to women’s health care.

Project Summary
Supervisor

Prof Karl Malcolm.


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