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Capturing complex vascular characteristics in efficient simulation of 3D, human-scale blood vessels

School of Mechanical and Aerospace Engineering | PHD
Funding
Funded
Reference Number
MAE2025/26JM
Application Deadline
6 January 2025
Start Date
1 October 2025

Overview

Cardiovascular disease is a significant cause of death and disability across the world. According to the British Heart Foundation, approximately 24% of deaths in Northern Ireland have cardiovascular diseases as a cause. Vascular structures can vary widely between individuals and this can significantly impact their chances of survival. In this project, you will develop and execute high resolution 3D models for blood flow in personalised vascular domains. This PhD will seek to address gaps in traditional approaches for simulating vascular flows and propose simulation tools that can help further understand the pathology of cardiovascular disease.

With the continued development of computational tools and resources, the concept of digital twins are more widely being deployed in engineering settings. Here a digital replica of a physical object is used to make predictions about its operational characteristics, maintenance requirements and performance optimisation. In the biomedical context, the concept of a virtual human twin seeks to offer similar benefits for the treatment of individual patients. Fundamental to this is the ability to generate reliable and personalisable simulations of a particular component of an individual’s physiology. Under the supervision of Dr Jon McCullough (lead) and Professor Ben Thornber (secondary), this project will focus on advancing the state-of-the-art in 3D vascular simulations for the study and understanding of cardiovascular diseases such as stroke or deep vein thrombosis. Such a model would have the potential to be utilised for greater clinical understanding of cardiovascular diseases and may be able to be coupled with other simulation models (e.g. heart or lungs) to build a larger virtual human twin.

Objectives:

Development of a validated, personalisable simulation tool for the study of cardiovascular disease.

Utilisation of the developed tool to develop insights into the factors impacting cardiovascular disease.

Interaction with clinical experts to ensure that the tool provides information relevant to the diagnosis/treatment of cardiovascular disease.

Efficient utilisation of modern computational fluid dynamics – high performance computers, modern CPU/GPU architectures, visualisation and analysis tools and software.

KEY TRANSFERABLE SKILLS
Code development (esp. for scientific simulation) – this PhD will require and develop skills in C++ and Python as well as understanding of open-source frameworks. You will execute your simulations on high-performance computers. Working with code for GPUs is possible.

Data management and analysis – computational simulations can generate large volumes of data that need to be effectively managed, analysed and visualised.

Communication and presentation skills – throughout your PhD you will summarise and present your findings to both expert and general audiences. You will disseminate your work in leading international journals and conferences.

IMPACT AND FUTURE CAREER PROSPECTS
Academic and industry applications of computational fluid dynamics are widespread in engineering including aerospace, wind turbines, battery design, power stations, industrial processes, aerosol dispersal, natural disasters, weather, and astronomy. This PhD will develop analytic, numerical, computational and project management skills that are sought after in many such employment settings. Although you will be immersed in the biomedical setting of your work, the skills will be transferrable to many other domains both as a postdoctoral or industrial researcher or in industry e.g. software engineering, consultancy (particularly, but not limited to, computational fluid dynamics).

INNOVATION AND INTERDISCIPLINARITY
This PhD will seek to benefit the medical domain through the use of engineering tools and analysis. You will make use of advanced tools for computational fluid dynamics and the analysis/visualisation of its output to effectively communicate your research outcomes. Discussions with clinical practitioners will help to ensure your work is relevant and useful to those working with patients with cardiovascular disease. Access to nationally, and possibly internationally, leading supercomputers using both CPU and GPU computations will form a foundation to the work and enable faster, more detailed and more personalised simulation results to be obtained.

Funding Information

UK studentships - cover tuition fees and include a maintenance stipend of £19,237 per annum, together representing an investment in your education of more than £70,000.
A UK studentship is open to UK and ROI nationals, and to EU nationals with settled status in the UK, subject to meeting specific nationality and residency criteria.
DfE studentship eligibility information can be viewed at: https://www.economy-ni.gov.uk/publications/student-finance-postgraduate-studentships-terms-and-conditions

Project Summary
Supervisor

Dr Jon McCullough

More Information

jon.mccullough@qub.ac.uk

Research Profile


Mode of Study

Full-time: Full Time


Apply now Register your interest

Mechanical Engineering overview

Our society needs exceptional engineers who can understand, create and harness technology to address our shared global challenges. Without these individuals our long-term success as technologically advanced societies and economies will be diminished. Undertaking a PhD in the School of Mechanical & Aerospace Engineering will enable you to make a real difference, positively impacting your career and through your research improving engineering methods and practice, and ultimately society.

Research undertaken by PhD students in the School of Mechanical & Aerospace Engineering forms a critical part of our research portfolio. Our research portfolio is ranked 24th in the UK with 96% of our Engineering research rated as world-leading or internationally excellent [REF 2021/ Times Higher Education]. What is more the REF2021 assessment, which is carried out by panels of academics and international experts, rated over 99% of the university research environment as world-leading or internationally excellent. Within this environment our PhD students research within the broad topics of design, materials, manufacturing, and energy.
Joining us as a PhD student you will be part of a dynamic environment and will study alongside students from many countries worldwide. It is a lively community of over 100 students, in which you will have the opportunity to develop both career and life skills, for example by participating in cohort training and mentoring programmes and student led social and cultural activities.

A PhD studentship is an investment in your personal development, worth over £100,000. Many of our PhD graduates take-up academic roles, while others go on to play leading roles in industry or become entrepreneurs. A PhD provides many benefits, among others it provides a range of “transferable skills”, such as independent and critical thinking, analytical and problem solving skills, leadership, and self-confidence. Because of these developed characteristics we see that many industry leaders hold a PhD. You will likely get a higher salary after graduation from a PhD than you do three years after an undergraduate degree. More importantly, you will get a different type of job and likely make progress faster through promotion and reward mechanisms. This, of course, depends on your ambition, but a PhD builds an exceptional career foundation.

Mechanical Engineering Highlights
Industry Links
  • The school boasts a number of strategic partnerships with world leading engineering companies. These partnerships enable our postgraduate students to forge vital links with industrial collaborators throughout their studies, gaining valuable exposure and real-world feedback. For example, the WTech Research Centre is working alongside Wrightbus to develop innovative and crucial global transport solutions. A dedicated team partnered with Rolls-Royce, is developing novel design approaches to deliver the aircraft of tomorrow. These partnerships, amongst others, mean PhD students can begin making real industry impact from year one of their studies.
World Class Facilities
  • The school encompasses world class facilities which are tailored to meet the needs of our students and research specialisms. Our materials testing laboratories can characterise a wide range of materials, including polymers and advanced composites. Our High Performance Computing (HPC) facility supports demanding numerical analysis such as Finite Element Analysis and Computational Fluid Dynamics. State-of-the-art manufacturing capabilities, including additive manufacture and robotics are powering research into The Factory of the Future.
    It is cutting edge facilities such as these, that give our PhD graduates a unique set of skills to enhance their future careers.
Internationally Renowned Experts
  • Undertaking a research degree in the School of Mechanical & Aerospace Engineering at Queen’s, you will work with and be supervised by world-leading experts in their respective fields.
Student Experience
  • An enhanced student experience is at the heart of what we do. As part of a diverse community of over 100 PhD students, you’ll be a valued part of a vibrant research community. You will benefit from a supportive mentoring program, a wide range of training opportunities and avail of the social events and wellbeing initiatives rolled out by our student-led Research Culture Committee.
Key Facts

Research students are encouraged to play a full and active role in relation to the wide range of research activities undertaken within the School and there are many resources available including:

  • The School has strategic research partnerships with a number of globally leading engineering companies, e.g. Rolls-Royce, Wrightbus, in which researchers undertake cutting edge and impactful research within multidisciplinary teams.
  • Access to state-of-the-art research laboratories and computing facilities (Northern Ireland High performance computing), along with office accommodation and opportunity to work within our aligned innovation centres
  • Access to the Queen’s University Postgraduate Researcher Development Programme and a wide range of personal development and specialist training courses.
  • A vibrant research community with opportunities to socialise, integrate and personally develop through student and university organised events.
  • Excellent graduate prospects ranging from academic, industrial to entrepreneurial opportunities.

Course content

Career Prospects

Employment after the Course
Dedicated to translating our research innovation into real world industrial and societal benefit. Many of our PhD graduates have moved into academic and research roles in Higher Education while others go on to play leading roles in industry, industry or become entrepreneurs. Queen's postgraduates reap exceptional benefits .

People teaching you

Dr Declan Nolan
Doctoral Programme Director
Mech & Aerospace Engineering
Email: d.nolan@qub.ac.uk

Course structure
Undertaking a PhD presents the opportunity to carry out novel research guided by dedicated supervisory teams who are built on expertise.

A PhD programme runs for 3-4 years full-time or 6-8 years part-time. Students can apply for a writing up year should it be required. Supervisors will offer feedback on the research work at regular intervals throughout the period of registration on the degree.

During the lifecycle of your research programme, you will be required to reach key milestones:

Initial Review – within three months (FTE) of first registration. A light touch progress meeting to establish the feasibility of the project and the research plan.

Differentiation – within nine months (FTE) of first registration. You will remain an ‘undifferentiated PhD student’ until this milestone has been completed wherein you will be required to satisfy academic staff that you are capable of undertaking a research degree.

Annual Progress Reviews – yearly thereafter Differentiation, requires students to present their work in writing and orally to a panel of academics. Successful completion of this process will allow students to register for the next academic year.

Viva voce [oral examination] - the final assessment of the doctoral degree is both oral and written. Students will submit their thesis to an internal and external examining team who will review the written thesis before inviting the student to orally defend their work at a Viva Voce.

Over the course of study, you can attend postgraduate skills training organised by the Graduate School, with opportunities to attend conferences and further training organised through your supervisor. Further growth and development opportunities are supported by community events (seminars, workshops, competitions, conferences etc) which are intentionally designed to provide platforms for showcasing your research to wider audiences.

Entrance requirements

Graduate
The minimum academic requirement for admission to a research degree programme is normally an Upper Second Class Honours degree from a UK or ROI HE provider, or an equivalent qualification acceptable to the University. Further information can be obtained by contacting the School.

International Students

For information on international qualification equivalents, please check the specific information for your country.

English Language Requirements

Evidence of an IELTS* score of 6.0, with not less than 5.5 in any component (*taken within the last 2 years) is required.

International students wishing to apply to Queen's University Belfast (and for whom English is not their first language), must be able to demonstrate their proficiency in English in order to benefit fully from their course of study or research. Non-EEA nationals must also satisfy UK Visas and Immigration (UKVI) immigration requirements for English language for visa purposes.

For more information on English Language requirements for EEA and non-EEA nationals see: www.qub.ac.uk/EnglishLanguageReqs.

If you need to improve your English language skills before you enter this degree programme, INTO Queen's University Belfast offers a range of English language courses. These intensive and flexible courses are designed to improve your English ability for admission to this degree.

Tuition Fees

Northern Ireland (NI) 1 TBC
Republic of Ireland (ROI) 2 TBC
England, Scotland or Wales (GB) 1 TBC
EU Other 3 £25,600
International £25,600

1 EU citizens in the EU Settlement Scheme, with settled or pre-settled status, are expected to be charged the NI or GB tuition fee based on where they are ordinarily resident, however this is provisional and subject to the publication of the Northern Ireland Assembly Student Fees Regulations. Students who are ROI nationals resident in GB are expected to be charged the GB fee, however this is provisional and subject to the publication of the Northern Ireland Assembly student fees Regulations.

2 It is expected that EU students who are ROI nationals resident in ROI will be eligible for NI tuition fees. The tuition fee set out above is provisional and subject to the publication of the Northern Ireland Assembly student fees Regulations.

3 EU Other students (excludes Republic of Ireland nationals living in GB, NI or ROI) are charged tuition fees in line with international fees.

All tuition fees quoted are for the academic year 2021-22, and relate to a single year of study unless stated otherwise. Tuition fees will be subject to an annual inflationary increase, unless explicitly stated otherwise.

More information on postgraduate tuition fees.

Mechanical Engineering costs

There are no specific additional course costs associated with this programme.

Additional course costs

All Students

Depending on the programme of study, there may also be other extra costs which are not covered by tuition fees, which students will need to consider when planning their studies . Students can borrow books and access online learning resources from any Queen's library. If students wish to purchase recommended texts, rather than borrow them from the University Library, prices per text can range from £30 to £100. Students should also budget between £30 to £100 per year for photocopying, memory sticks and printing charges. Students may wish to consider purchasing an electronic device; costs will vary depending on the specification of the model chosen. There are also additional charges for graduation ceremonies, and library fines. In undertaking a research project students may incur costs associated with transport and/or materials, and there will also be additional costs for printing and binding the thesis. There may also be individually tailored research project expenses and students should consult directly with the School for further information.

Bench fees

Some research programmes incur an additional annual charge on top of the tuition fees, often referred to as a bench fee. Bench fees are charged when a programme (or a specific project) incurs extra costs such as those involved with specialist laboratory or field work. If you are required to pay bench fees they will be detailed on your offer letter. If you have any questions about Bench Fees these should be raised with your School at the application stage. Please note that, if you are being funded you will need to ensure your sponsor is aware of and has agreed to fund these additional costs before accepting your place.

How do I fund my study?

1.PhD Opportunities

Find PhD opportunities and funded studentships by subject area.

2.Funded Doctoral Training Programmes

We offer numerous opportunities for funded doctoral study in a world-class research environment. Our centres and partnerships, aim to seek out and nurture outstanding postgraduate research students, and provide targeted training and skills development.

3.PhD loans

The Government offers doctoral loans of up to £26,445 for PhDs and equivalent postgraduate research programmes for English- or Welsh-resident UK and EU students.

4.International Scholarships

Information on Postgraduate Research scholarships for international students.

Funding and Scholarships

The Funding & Scholarship Finder helps prospective and current students find funding to help cover costs towards a whole range of study related expenses.

How to Apply

Apply using our online Postgraduate Applications Portal and follow the step-by-step instructions on how to apply.

Find a supervisor

If you're interested in a particular project, we suggest you contact the relevant academic before you apply, to introduce yourself and ask questions.

To find a potential supervisor aligned with your area of interest, or if you are unsure of who to contact, look through the staff profiles linked here.

You might be asked to provide a short outline of your proposal to help us identify potential supervisors.

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