Skip to Content

Developing a vaccine against Staphylococcus aureus using a reverse vaccinology approach

School of Medicine, Dentistry and Biomedical Sciences | PHD

Applications are now CLOSED
Funding
Funded
Reference Number
SMED-2231-1235
Application Deadline
23 February 2023
Start Date
1 October 2023

Overview

With ever-increasing antimicrobial resistance, there is an urgent need for vaccines against bacterial pathogens. Staphylococcus aureus is a leading cause of antimicrobial resistant infections. We have developed a reverse vaccinology approach to identifying bacterial vaccine candidates, this project will apply this approach to S. aureus.

Staphylococcus aureus is a leading cause of antimicrobial resistant infections, in hospitals it is the most frequently associated gram-positive bacteria causing ventilator associated pneumonia in ICU patients. There are currently no licensed vaccines against S. aureus. We have developed a reverse vaccinology approach to identifying bacterial vaccine candidates, this project will apply this approach to S. aureus. This will involve both in silico analysis, cloning, protein expression and in vitro screening using memory T cells. The targets identified in this and a parallel project at UCD will then be evaluated using in vivo protection models. This project will allow the students to develop a broad range of skills in fundamental vaccine development

Funding Information

HEA North-South Grant – AVACTA (awarded) To be considered eligible you must have been ordinarily resident in the UK for the full 3 year period prior to the start of the studentship and you must be ordinarily resident in Northern Ireland on the first day of the start of the studentship.

Project Summary
Supervisor

Dr Beckie Ingram

More Information

askmhls@qub.ac.uk

Research Profile


Mode of Study

Full-time: 3 years


Funding Body
HEA North-South Grant – AVACTA (awarded)
Apply now Register your interest