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Development of antioxidants-based nanoparticles for topical application

School of Pharmacy | PHD
Funding
Unfunded
Reference Number
PMY/2251/TH2
Application Deadline
31 January 2025
Start Date
1 October 2025

Overview

Skin is one of the most organs of the human body exposed to irritants, pollutants and xenobiotics from the environment. Skin health and safety is based on skins’ endogenous antioxidants reserves. Exogenous supplementation of antioxidants to the skin is a vital option in supporting diseased, aged or sun exposed skin. Lipid nanocapsules (LNCs) are interesting nano formulation. The manufacturing method is easy scalable and with predictive ability of the particles size before the beginning of the manufacturing. LNCs are small, enable the particles to stick to surfaces such as skin which can have a lot of potential in exogenous antioxidant supplementation. LNCs can be used to load hydrophobic and amphophilic molecules, making it a very versatile for different types of drugs and ingredients. LNCs have several particle sizes and versatile composition, making LNCs a platform for drug delivery with skin compatible composition. The successful applicant will work as part of a world-leading research group with widely reputed expertise in drug delivery. The applicant will be expertly trained in key skills pertaining to drug delivery, pharmaceutical formulation and analytical testing of drug products.

The project will provide hands-on training for the student in the following techniques:

Nanoparticles drug formulation methods and characterisation

preparation and characterisation of drug delivery hydrogels gels

drug quantification using high performance liquid chromatography (HPLC)

in vitro drug release testing

thermal analysis methods

in vitro cellular testing

antioxidant activity examination

As an integral part of the project, the student will further develop the following key skills:

planning and organising designing and planning of experiments

numeracy and statistical skills

teamwork: working confidently as part of a large research team

We anticipate that the project will lead to new gel-based products with increased efficacy against bacterial infections.

Project Summary
Supervisor

Dr Taher Hatahet

t.hatahet@qub.ac.uk

Research Profile


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