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Enhancing therapeutic responses in DLBCL through advanced understanding of new metabolic regulators

School of Medicine, Dentistry and Biomedical Sciences | PHD

Applications are now CLOSED
Funding
Funded
Reference Number
SMED_2241_1027
Application Deadline
10 April 2024
Start Date
1 October 2024

Overview

Investigating a novel role for E3 ubiquitin ligase in the progression of diffuse large B cell lymphoma using gene editing and metabolomics

We have identified a novel role for a Pellino1 E3 ubiquitin ligase in B cell activation. Ubiquitination is a crucial protein modification which can modulate protein-protein interactions, signalling cascade, and protein degradation. Interestingly, Pellino1 is overexpressed in many diffuse large B cell lymphomas (DLBCL), a malignancy accounting for around one third of non-Hodgkin lymphomas.

Early data points to a role for Pellino1-mediated ubiquitination in regulation of cellular metabolism and this project aims to investigate how Pellino1 regulates B cell activation and metabolic programming, as well as effects on therapeutic sensitivity in DLBCL. The project likely involves flow cytometry, metabolomics and molecular biology, including CRISPR. It would suit candidates interested in cancer biology, cell biology and genetic engineering, and immunology.

Funding Information

This is a competitive award, there are five advertised projects for two studentship awards

To be considered eligible you must have been ordinarily resident in the UK for the full 3-year period prior to the start of the studentship and you must be ordinarily resident in Northern Ireland on the first day of the start of the studentship. If successful, support will be provided by an LLNI studentship.

The value of an award includes the cost of approved tuition fees and maintenance support, rates for 2024/25 are Fees £4,786, Stipend £19,479 with an inflationary uplift in subsequent years

Project Summary
Supervisor

Dr Dessi Malinova

More Information

askmhls@qub.ac.uk

Research Profile


Mode of Study

Full-time: 3 Years


Funding Body
LLNI
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