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Improving antimicrobial delivery via nanoparticles

School of Pharmacy | PHD
Funding
Unfunded
Reference Number
PMY/2251/JB3
Application Deadline
31 January 2025
Start Date
1 October 2025

Overview

Antimicrobial resistant bacteria are a major issue, and new ways are needed to target bacterial infections more efficiently. One way in which bacteria can avoid antimicrobial drugs is by hiding within our own cells. Multiple bacteria can establish intracellular infections, and much work has focussed on delivering antimicrobials into cells via various mechanisms. We have shown that nanoparticles can deliver antibiotics to combat intracellular infections. In addition, we observed that altering some parameters of nanoparticles can increase their cellular uptake and improve their efficacy. However, we also found that some bacterial species reside in compartments within the cell these nanoparticles don’t reach. Therefore, this project will further investigate how we can alter these nanoparticles to improve their intracellular uptake and improve their antimicrobial efficacy. In addition, it will examine how nanoparticles can be adapted to target bacteria which reside at alternate locations within the cell.

The student will be part of a cross-disciplinary team based in the School of Pharmacy and will have the opportunity to learn a broad range of molecular biology, tissue culture, bacterial culture, and cell biology related techniques, as well as developing transferable skills such as written and verbal scientific presentation skills.

Project Summary
Supervisor

Dr James Burrows & Professor Brendan Gilmore


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