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Remote assessment for clinical trials and healthcare: Exploring the usefulness of remote spirometry  

School of Medicine, Dentistry and Biomedical Sciences | PHD
Funding
Unfunded
Reference Number
SMED-2231-1232
Application Deadline
None specified
Start Date
None specified

Overview

The COVID-19 pandemic and pressure on healthcare systems has increased use of remote spirometry for monitoring of respiratory patients. These portable spirometers have been advocated by healthcare providers and positively received by patients, however, no conclusive evidence that measurements from remote spirometry are valid and reliable. This project seeks to investigate the validity and reliability of remote spirometry.

The aim of this PhD project is to investigate the validity and reliability of remote spirometry and explore its usefulness in supporting clinical trials and healthcare services.



Traditionally, patients perform spirometry in a clinic setting supervised by a trained professional under standardised conditions (1, 2). Spirometry is used extensively for diagnosis and monitoring patients with respiratory conditions, where measurements are used to assess disease severity and control (3-5). In clinical research, lung function is an important outcome measure to assess intervention efficacy (6-8), and is a constituent of clinical trial core outcome sets for COPD(9), bronchiectasis(10) and pulmonary infections(11).



However, accelerated by the COVID-19 pandemic and with increased pressure on healthcare systems, routine respiratory services and clinical trials have now adopted remote spirometry (13-15). These portable spirometers have been advocated by healthcare providers (16-18) and have been positively received by patients (19-22). It is crucial to know whether remote spirometry measurements are valid and reliable before mass uptake. Remote spirometry could support virtual healthcare services in routine care and enable for more pragmatic trial design (23) such as the development and scaling of decentralised clinical trials (24).



Objectives:

Summarise the evidence on reproducibility of spirometry measurements over time and explore of there are any patient/centre factors that influence reproducibility (Study 1).

Compare clinic supervised spirometry to remote unsupervised spirometry during periods of stability in bronchiectasis patients using data from current clinical trial sets. This study will also explore if there are any patient/centre factors that influence associations (Study 2).

Explore if lung function can be used as a predictor for exacerbations or recovery from an exacerbation using data using data from current clinical trial sets (Study 3).

Explore current research and clinical practice investigators on remote spirometry across the UK (Study 4)

Explore patterns of adherence to remote monitoring and explore the quality of remote monitoring as well as patient / centre level correlates (Study 5)

Project Summary
Supervisor

Professor Judy Bradley

More Information

judy.bradley@qub.ac.uk

Research Profile


Mode of Study

Full-time: 3 Years


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