My main research interest are centred around the biochemistry of human RNA Polymerase I (Pol-I) transcription machinery, molecular and cellular mechanisms involved in the regulation of ribosomal RNA (rRNA) synthesis including signal transduction and epigenetic mechanisms, and discovery of novel drugs targeting rRNA transcription.

The level of ribosomal RNA synthesis by Pol-I is rate-limiting to ribosome biogenesis and therefore has a major influence on the cellular capacity for protein production, making Pol-I transcription fundamental to life. Elevated levels of rRNA synthesis are required to support the unrestrained proliferation of cancer cells making rRNA synthesis a valid target for anticancer therapy as well as providing opportunities for the diagnosis of cancer. On the other hand, drugs promoting rRNA synthesis might be useful for stimulation of cell growth and proliferation in cell-replacement therapy strategies.