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Dr Joseph S. Vyle

School of Chemistry and Chemical Engineering

Dr Joseph S. Vyle

School of Chemistry and Chemical Engineering

In collaboration with the School of Pharmacy (Professor Helen McCarthy), we are developing methods which will allow the delivery of phosphorylated drugs and prodrugs to cancer via nanoparticles. Our specific interest is in the modification of nucleic acids with selenium which increases the nuclease stability of DNA and RNA but can enable drug release upon encountering the pathophysiological conditions encountered in the tumour microenvironment. Selenium also provides valuable structural information about biologically-active conformations both in solution and crystalline material.

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Research Interests

Open to PhD applications in:

DNA analogue synthesis, delivery and solid state NMR

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Public outreach & key achievements

Demonstration lectures to A-level chemistry students

Research students

Lawrence Hale, Synthesis and evaluation of biologically-active nucleic acids delivered by RALA, 2021-2024, UK

Alumni: Where are they now

Olga Eguaogie, Nucleoside and nucleotide analogues containing chalcogens, 2014-2017, Germany, Almac

Patrick F. Conlon, Novel Approaches to the synthesis of selenium modified nucleosides, nucleotides and nucleic acids, 2016-2019, Almac, N. Ireland, Almac

Jordan J. Wilson, Forging novel anticancer agents and cellular espionage using RALA, 2018-2021, UK, pHionX

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Postgraduate research

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Chemistry and Chemical Engineering

Find a PhD Supervisor

Dr Joseph S. Vyle

Dr Joseph S. Vyle

Contact info

Research Interests

Public outreach & key achievements

Research students

Alumni: Where are they now

Discover More

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