Dr. Margarone's main research interests are in the areas of laser driven ion acceleration, innovative target geometries for ion acceleration, real-time diagnostics of particles and radiation generated in laser-plasmas, generation of brilliant particle streams from nuclear fusion reactions, production of laser-based secondary sources for multidisciplinary applications, including new compact approaches to hadrontherapy for cancer treatment and enhancement of cancer cell killing efficacy through the proton boron nuclear fusion reaction.