Cochrane systematic review: Multimodal interventions which aim to alleviate and/or stabilize cachexia ...
Project Title |
Cochrane systematic review: Multimodal interventions which aim to alleviate and/or stabilize cachexia (disease-related wasting) for individuals with a chronic illness
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Research Focus |
Chronic illness, cachexia, multimodal interventions |
Funder & Dates |
This work is co-funded by the HSC R&D Division, Public Health Agency [Award reference: COM/5726/22] and the Northern Ireland Kidney Research Fund (NIKRF). October 2022 – October 2024 |
Principal Investigator or Primary Supervisor (if PhD project) |
Professor Joanne Reid |
Co-Investigators or additional supervisors |
Dr Carolyn Blair, Dr Clare McKeaveney, Professor Martin Dempster, Dr Adrian Slee, Professor Donna Fitzsimons |
Research Fellow(s) or PhD Student |
Dr Carolyn Blair (RF) |
Name & Institution of Collaborators |
Professor Joanne Reid1, Dr Carolyn Blair1, Dr Clare McKeaveney1, Professor Martin Dempster2, Dr Adrian Slee3, Professor Donna Fitzsimons1 1 School of Nursing and Midwifery, Queen's University Belfast, Belfast, UK. 2 School of Psychology, Queen's University Belfast, Belfast, UK. 3Division of Medicine, Faculty of Medical Sciences, University College London, UK. |
Name of External Partner Organisations |
The Cochrane Pain, Palliative and Supportive Care Review Group (PaPaS) HSC R&D Division, Public Health Agency Northern Ireland Kidney Research Fund (NIKRF) |
Description of Project: Aim; Methods; Expected Outcomes
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Background: Previous reviews have summarized the applicability of multimodal interventions (Aapro, Arends et al. 2014, Del Fabbro 2019) and in the first critical review of multimodal interventions for cachexia (McKeaveney, Maxwell et al. 2021), there is a clear consensus that unimodal therapies will not stabilize or reverse cachexia (Di Girolamo, Guadagni et al. 2019). However, despite growing and intensive research in the field, relatively little is known about the most effective multimodal treatment options to counteract and manage cachexia therefore no standardized treatment exists (Crawford 2019). Relatedly, practice guidelines on cachexia management are absent and urgently needed to inform treatment pathways for clinicians treating patients with cachexia and more generally on chronic diseases. Health care practitioners need guidance on how individuals with cachexia can improve functioning, maintain and gain weight to enhance their opportunity for survival and an improved quality of life (von Haehling, Anker et al. 2016). It is evident that for patients with or at risk of cachexia, a comprehensive multimodal strategy is required (Fearon, Argiles et al. 2015) therefore this Cochrane review is required to needed to assess the safety and efficacy of such interventions. Our aim is that the findings will influence treatment guidelines and future RCTs building evidence for more effective treatments and thereby improve patient outcomes. Objectives: To assess the following:
Methods: We will identify, appraise and synthesize all the empirical evidence that meets our pre-specified eligibility criteria to fulfil the aforementioned objectives. Our review will be conducted in accordance with Cochrane guidance and in collaboration with the Cochrane Pain, Palliative and Supportive Care Review Group (PaPaS). |