The focus of my research is drug resistance. Originally focused on resistance to standard-of-care chemotherapy in colorectal cancer, this work has broadened to include mechanisms of drug resistance in multiple cancers.

The mechanism of drug resistance that I have focused on most is cell death, particularly apoptosis. My most significant achievement in this area has been identification of the apoptosis-regulating protein FLIP as a key mediator of drug resistance, a biomarker of poor prognosis and potential therapeutic target for cancer.