We use interdisciplinary approaches including molecular genetics, biochemistry, cell biology, and structural biology to understand the pathogenesis of opportunistic Gram-negative bacteria at molecular and cellular levels. Burkholderia, Achromobacter, and Enterobacter species are the main model organisms we use in different aspects of our research program.

Current interests are: (i) To advance the understanding of the assembly and modifications of lipopolysaccharide (LPS) and glycosylation of envelope proteins; (ii) To elucidate the molecular basis of intrinsic multidrug antibiotic resistance in resilient opportunities Gram-negative pathogens; and (iii) to exploit our finding to develop novel means to combat antibiotic resistant pathogens.