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How the interactome defines the biological activity of members of the KDM4A subfamily of histone demethylases

School of Biological Sciences | PHD

Applications are now CLOSED
Funding
Funded
Reference Number
SBIO-2020-1251
Application Deadline
24 March 2023
Start Date
1 October 2023

Overview

The expression of members of the KDM4A-subfamily of histone demethylases is impaired in various cancers. Different signalling pathways regulate the KDM4A-subfamily interactome, thereby affecting the biological activity of these enzymes. The main goal of this project is to test this hypothesis by studying the KDM4A-subfamily interactome and post-translational modifications.

Members of the KDM4A histone demethylase subfamily (includes KDM4A, B, and C) play important roles in various biological processes by regulating differentiation, double-strand break repair, proliferation, cell cycle, genome stability, metabolic response, and stress response. Expression of members of the KDM4A subfamily is impaired in a variety of cancers (including difficult-to-treat pancreatic cancer, colorectal cancer, and triple-negative breast cancer). Members of the KDM4A subfamily are viewed by many as a promising target for anticancer therapy. However, the pleiotropic activity of these enzymes makes it difficult to develop treatments that target only specific activities involved in oncogenesis.

Our and published data indicate that these enzymes are part of multisubunit complexes that perform distinct functions. We hypothesize that various signalling pathways (including those that are de-regulated in certain types of cancer) target components of such complexes that influence their composition. This will affect the activity, cellular localization and recruitment of these enzymes. The main goal of this project is to test this hypothesis by studying the KDM4A, B and C interactomes and post-translational modifications using protein mass spectrometry and find out if this represents a vulnerability that can be exploited therapeutically.

Start Date: 1 October 2023

Duration: 3 years

How to apply: Applications must be submitted online via: https://dap.qub.ac.uk/portal/user/u_login.php

Funding Information

Applicants for this and a number of other projects will be in competition for studentships funded by the Northern Ireland Department for the Economy (DfE).
Candidates must be normally resident in the UK for the three year period prior to 1 September 2023. For non-EU nationals, the main purpose of residence must not have been to receive full-time education. Non-UK or Irish nationals must also have pre-settled or settled status (EU nationals) or settled status (non-EU nationals).
Full eligibility criteria: https://www.economy-ni.gov.uk/publications/student-finance-postgraduate-studentships-terms-and-conditions

Project Summary
Supervisor

Dr Konstantin Panov

More Information

askmhls@qub.ac.uk

Research Profile


Mode of Study

Full-time: 3 years


Funding Body
DfE
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